Biostimulators and regenerative treatments are gaining traction in aesthetic medicine, capturing the attention of both providers and patients.Emphasizing gradual rejuvenation for natural, long lasting results, these techniques utilize the patient’s own tissues to address concerns like volume loss.Noteworthy substances such as Poly L Lactic Acid (PLLA), calcium hydroxylapatite (CaHA), polynucleotides, exosomes, and platelet-rich plasma are employed to enhance skin architecture and function.By promoting collagen, elastin, and other crucial elements in the extracellular matrix, these methods contribute to skin rejuvenation and overall improved skin quality.